Immunology Lecture Overview Chapter 17

Humoral immunity

Cell mediated immunoty

Lymphocytes

B cells

T cells

T_h (CD4⁺)

T_c (CD8⁺)

T_d

Clonal selection(Burnett) of B cells (memory; plasma cells)

Central role of T_h cells

APC (Antigen presenting cells)

MHC (human chromosome 6; mouse chromosome 17)

Class I molecules (Interact with T_c)

Class II molecules (Interact with T_h)

T cell receptor (TCR)

Generation of diversity

The anamnestic response (memory, booster)

Affinity maturation

Antibody structure

5 classes of antibodies

IgM

IgA

IgD

IgE

IgG

The "class switch"

Epitopes (determinants)

Haptens

Monoclonal antibodies

Complement

Complement fixation

Active immunity

Passive immunity